Road transport is one of the biggest sources of GHG emissions in the EU. Europe’s transport emissions account for 25% of total GHG emissions in the EU13. In the heavy duty long haulage transport sector, the reduction of real driving emissions, fuel consumption and its related CO2 emissions is the main societal challenge. The LONGRUN project will contribute to lower the impacts by developing different engines, drivelines and demonstrator vehicles with 10% energy saving (Tank to Wheel) and related CO2 reduction, 30% lower emission exhaust (NOx, CO and others) and 50% Thermal Efficiency. The European Commission has proposed sharp targets to reduce CO2-emissions of minus 15% by 2025 (compared to 2019) and minus 30% by 2030 (compared to 2019) to counter the growth in transport and related emissions14. The review of the CO2 emission standards for heavy-duty vehicles will be starting in 2022 and LONGRUN results will be just in time to feed into and support the decision-making process.